“Norcoline” for short, and also known as Higenamine, you’ve probably seen this ingredient in USP Lab’s Jack3d Micro or their new OxyElite Pro formula. So what does it do, why is it effective, and is this something that could work for most people?
We’ll delve into the details to give you a better idea of what this stuff does.
What is Norcoclaurine and what does it do?
An article on examine.com provides some basic insight of its use. Essentially Norcoline is a beta(1 and 2) receptor agonist similar to ephedrine. For those of you who know about or have used ephedrine or ephedra-based products, you know that it shreds fat. It’s also a bronchodilator that can be used to tread asthmatic symptoms. Another function is that it is an effective anti-inflammatory. These functions are nothing but beneficial for a large majority of people.
The beta receptor agonist function showed promise in one study, due to its abilities to increase plasma and intracellular cAMP levels. The only issue with this function is that its half-life in human bioavailability is 8 – 16 minutes long. The article states that Norcoline has the most potential of any stimulant since 1,3 DMAA. It may, however, be a safer alternative to 1,3 DMAA. Simply put, this stuff will enhance metabolic pathways to speed up lipolysis.
You may be asking yourself why having a bronchodilator in your pre workout or fat burner would be beneficial, especially if you don’t have asthma. Well, if you were able to take in deeper, fuller breaths and have more endurance as a result, wouldn’t that be beneficial?
If you have exercise-induced asthma, you will greatly benefit from having a bronchodilator. It helps shuttle oxygen and nutrients into the blood stream, and into the muscle you’re working out. This process will enhance the ability to keep going, and reduce muscle soreness later. One scientific study shows that Higenamine is the key component to relief of bronchoconstriction, further solidifying the anti-asthmatic effects of Norcoline.
Another function Norcoline provides is the release of acetylcholine, which helps maximize muscular output. The dose to effectively achieve spontaneous release of acetylcholine has yet to be determined. Release of acetylcholine increases skeletal (voluntary) contractile strength, making users more able to put more weight up.
To push fat burning even further, Norcoline shows strong potential in reducing the anti-lipolytic effects of alpha-2 andrenoceptors. Stimulating fat loss by activating the beta 1 and 2 andrenergic receptors coupled with avoiding the storage of fat brought on by the alpha-2 andrenoceptors makes a killer fat burning ingredient.
Norcoline shows anti-thrombotic and blood pressure reduction capabilities as well. When working out at a moderate to high intensity, this benefits achieving a healthier state of cardiovascular health. One study concludes that Norcoline increases recovery from acute thrombosis in both rats and humans. It also discusses the anti-platelet properties to prevent cardiovascular build up of plaque.
For our male readers…this next function is for you. In conjunction with PDE5 inhibitors like horny goat weed, Norcoline creates a synergy that can be used to treat erectile dysfunction. Surprising? It was to us too. Nothing wrong with a little help in the bedroom, is there?
To summarize it all up, Norcoline is a potent fat burner that shreds you up, allows you to breath better, can help with muscle performance, improves cardiovascular health, and can even give you a boost in the bedroom (for guys). It’s a very versatile compound that we presume will be heavily used in future fat burning products and pre workouts. Whatever your goals are, Norcoline is an awesome ingredient, which really shines as a new part of OxyELITE Pro.
- Effects of higenamine on the cardio-circulatory system. Zhongguo Zhong, Yao Za Zhi. 2003 Oct 28.
- Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1. Bai G, Yang Y, Shi Q, Liu Z, Zhang Q, Zhu YY.
- Anti-thrombotic effects of higenamine. Yun-Choi HS, Pyo MK, Park KM, Chang KC, Lee DH.
- USP's JM Q&A